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KMID : 0880520120480030141
Chonnam Medical Journal
2012 Volume.48 No. 3 p.141 ~ p.149
Coronary Stent Thrombosis: Current Insights into New Drug-Eluting Stent Designs
Kim Hyun-Kuk

Jeong Myung-Ho
Abstract
The advances of interventional cardiology have been achieved by new device development, finding appropriate drug regimes, and understanding of pathomechanism. Drug-eluting stents (DES) implantation with dual anti-platelet therapy reduced revascularization without increasing mortality or myocardial infarction compared with bare-metal stenting. However, late-term stent thrombosis (ST) and restenosis limited its value and raised the safety concern. Main mechanisms of this phenomenon are impaired endothelialization and hypersensitivity reaction with polymer. The second generation DES further improved safety and/or efficacy by using thinner stent strut and biocompatible polymer. Recently, new concept DES with biodegradable polymer, polymer-free and bioabsorbable scaffold are under investigation in the quest to minimize the risk of ST.
KEYWORD
Drug-eluting stents, Coronary thrombosis, Blood platelets
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